Read on for more information on our top picks.
Our Editor’s Best Mattress Cleaner Spray Reviews
Rocco & Roxie Oxy Stain Remover – Oxygen Powered Carpet Cleaner Spray – Spot Cleaner for Upholstery, Couch, Laundry, Rug, Clothes, Car Seat, Mattress, Sofa, and More. – Pet & Baby Stains

Key Features:
-
This mattress cleaner spray is ideal for removing stains quickly and easily. The activated oxygen technology breaks up stains right before your eyes, and eliminates them at the source so they never come back.
-
This mattress cleaner spray is tough on stains and can remove set-in stains caused by urine, feces, vomit, blood, dirt, grass, juice, chocolate, coffee, tea, blueberries, tomato sauce, ink, red wine and much more.
-
This is a gentle mattress cleaner spray that is chlorine free and color safe. It is certified safe for use on all carpet types and has earned the Seal of Approval from the trusted Carpet and Rug Institute (CRI). It will not leave residue that will attract dirt or leave your carpet feeling crunchy.
-
This mattress cleaner spray is for people who want to clean their mattresses quickly and easily. The spray is for tough stains on carpet, upholstery, laundry, and all water-safe surfaces.
-
This mattress cleaner spray is safe to use around pets and children, and does not contain any hazardous propellants.
BISSELL Little Green Multi-Purpose Portable Carpet and Upholstery Cleaner, 1400B

Key Features:
-
This is a mattress cleaner spray that also helps support a foundation that saves homeless pets.
-
Spray and forget about those stains! With this powerful mattress cleaner spray, you can easily remove spots and stains from carpets, upholstery, car interiors, and more.
-
This mattress cleaner spray is strong enough to remove tough pet stains, and it has suction to help remove the stains quickly.
-
The mattress cleaner spray has a large tank capacity of 48 ounces, so you can clean more between refills.
-
The description states that the product comes with a 3″ Tough Stain Tool, HydroRinse Self-Cleaning Hose Tool, and an 8 oz. trial-size Spot & Stain with Febreze Freshness formula. This product is designed to clean mattresses and is said to be easy to use.
-
This mattress cleaner spray is a product of The Procter & Gamble Company. It is used to clean mattresses and remove stains. The spray is available in a variety of scents.
Rocco & Roxie Stain & Odor Eliminator for Strong Odor – Enzyme-Powered Pet Odor Eliminator for Home – Carpet Stain Remover for Cats and Dog Pee – Enzymatic Cat Urine Destroyer – Carpet Cleaner Spray

Key Features:
-
If you’re looking for a gentle and safe mattress cleaner spray, this is the one for you! It’s chlorine free and color safe, and it’s safe to use around pets and children. Plus, there are no hazardous propellants and no residue is left behind. It’s so gentle that it’s been certified safe for all carpets, earning the seal of approval by the trusted Carpet and Rug Institute (CRI).
-
This mattress cleaner spray eliminates stains, odors and residue. It is a professional strength formula that tackles all types of organic spills.
-
This mattress cleaner spray can be used on any surface to remove stains. It is safe to use around pets and children.
-
This spray contains natural enzymes that are activated on contact with odors and stains, feeding on ammonia crystals and organic matter until they are completely eliminated.
-
If you are not satisfied with this mattress cleaner spray, you can get your money back.
Good Life Solutions Natural Odor and Stain Remover Spray – Unscented Plant-Based Child and Pet Safe Cleaner Earth-Friendly Odor Eliminator Eco Cleaning Products for Home, Carpet, Upholstery 32oz

Key Features:
-
This mattress cleaner spray is a natural, plant-based formula that is tough on stains. It is unscented and fragrance-free. This cleaner spray is safe for kids and pets. It works well as a stain, odor and urine remover throughout your home or workplace.
-
This mattress cleaner spray is a powerful laundry stain and pet urine remover that is made in the USA. The formula is biodegradable and the packaging is fully recyclable.
-
The mattress cleaner spray is an enzymatic advanced stain remover that is designed to break down and remove tough stains from potty training messes to wine on the furniture. The formula contains active ingredients – not chemicals – that break down stains and remove them for good.
-
This mattress cleaner spray is good for removing stains on water-safe fabrics and surfaces. You can use it on your mattress, upholstery, or fabric, carpet, floors, or cribs. It’s also effective in removing blood.
-
This mattress cleaner spray is tough on stains, safe for kids and pets, and all natural. If you’re not satisfied with the product, the company will refund your purchase.
Resolve Urine Destroyer Spray Stain & Odor Remover, Transparent, No Flavor, 32 Fl Oz

Key Features:
-
This mattress cleaner spray is designed to neutralize odors on contact. It is effective against a variety of odors, including sweat, urine, and smoke.
-
This mattress cleaner spray is great for pet and human accidents. It quickly and easily removes stains and odors, leaving your mattress clean and fresh.
-
This is a mattress cleaner spray that is safe for carpets, fabrics, and hard floors.
-
This mattress cleaner spray is designed to help prevent remarking, or the formation of new stains on your mattress. It can be used on both fresh and old stains, and is safe for all types of fabrics.
-
If you have pets, you can still use this mattress cleaner spray! Just be sure to follow the directions.
FOLEX Instant Carpet Spot Remover, 32oz

Key Features:
-
If you are looking for a mattress cleaner spray that can remove pet accidents, grease, oil, ink, red wine, coffee, blood, rust, food, cosmetics, dirt, and grime, then this is the cleaner for you!
-
This mattress cleaner spray is water-based, non-flammable, and odor free. It is safe to use on all types of mattresses, including memory foam, latex, and coil.
-
This mattress cleaner spray is free of VOCs, solvents, and petroleum.
-
This mattress cleaner spray is safe to use around children and pets if used as directed.
-
This mattress cleaner spray is made in the USA and is designed to clean your mattress quickly and easily.
-
This mattress cleaner spray comes in a 1-bottle size. It is designed to clean mattresses and remove stains.
CHATEAU SPILL Red Wine Stain Remover for Clothes – 4oz Safe Stain Remover Spray for Stubborn Stains – Cleaner Wipes Away New and Set on Tablecloth, Garment, Carpet, Upholstery and Laundry

Key Features:
-
If you’re a red wine lover, this is the mattress cleaner spray for you! It’s been reviewed by Wired Magazine as the best red wine stain remover for both fresh and old stains, so you can use it with confidence.
-
This mattress cleaner is powerful and fast-acting, ideal for removing wine stains from clothing, carpets, and upholstered furniture. It can be used immediately on the spot or as a pretreatment before laundry.
-
This mattress cleaner spray is a non-toxic and effective way to clean your mattress. It is made with no peroxide, chlorine, phosphates, sulphates or parabens. The biodegradable pH neutral laundry stain remover is tough on wine, but not your wardrobe, rugs, or bedding.
-
The spray is designed to be used on fresh or dry stains, and will cause them to disappear. It can be used on clothing while out and about, and the wipes (sold separately) can be carried with you in case of stains.
-
This mattress cleaner spray is in a wine bottle design, making it a fun and practical gift for any wine lover. The Chateau Spill is a powerful treatment that is perfect for travel.
Hoover Deep Stain Remover Aerosol Spray, Carpet and Upholstery Spot Cleaner, 15 oz Cleaning Solution, AH30903, White

Key Features:
-
If you are looking for a mattress cleaner spray that is maximum strength and can break down tough spots and stains, then this is the cleaner for you. This cleaner is great for removing stains like red wine, coffee, makeup, mud, motor oil, greasy foods and more.
-
The mattress cleaner spray is designed to clean stains deeply and quickly. The high power spray action trigger makes it easy to use, and the formula is effective on a variety of different types of stains.
-
This mattress cleaner spray is easy to use: just shake it, spray it, let it stand, blot it, and repeat until the stain is gone.
-
This is a multi-surface cleaner that can be used on carpet, area rugs, upholstery and car interiors.
-
This mattress cleaner spray is made in the USA with US and globally sourced materials.
-
This mattress cleaner spray is safe to use around children and pets when used as directed.
Klean Logik Mattress Cleaner Spray, Mattress Stain Remover For Urine, Blood, Vomit, Coffee, & Various Deep Fabric Stains! Mattress Stain Cleaner W/ Odor Absorbing Fresh Scent, 8 Fl Oz

Key Features:
-
This mattress cleaner spray is easy to use. Simply spray the stain directly and let it work.
-
This mattress cleaner spray is formulated to remove tough stains like human urine, wine, blood, vomit, and coffee. It uses pro-enzyme power to break down the stains, making them easier to remove.
-
The Spot Cleaner for Mattress is a great way to clean up any spills or stains on your mattress while also freshening it up with a great smelling scent. This cleaner is perfect for those who want to keep their mattress looking and smelling great.
-
This mattress cleaner spray will allow you to have a clean and fresh mattress, free of any stains. Simply spray on the desired area and let it dry, and your mattress will be as good as new!
-
This mattress cleaner spray is made in the USA and comes with a 100% money back guarantee!
Good Life Solutions All-Purpose Cleaner Spray – Natural Plant Based Multi Surface Cleaner with Citrus, Child and Pet Safe Earth-Friendly Eco Cleaning Products for Home, No Added Fragrance – 32 fl. oz.

Key Features:
-
This is a powerful natural spray cleaner that is tough on stains. It is made with hydrogen peroxide and is fragrance-free. It is also safe for kids and pets.
-
This is an earth-friendly surface spray that is made in the USA. The formula is biodegradable and the packaging is fully recyclable. The spray is powerful and can be used for a variety of purposes. The company does not test on animals.
-
This mattress cleaner spray is designed to remove tough non-organic stains from your mattress, furniture, and flooring. The active ingredients in the formula will lift and remove stains quickly and easily, without the use of harsh chemicals. This product is also safe for use around pets.
-
This mattress cleaner spray is safe to use on all water-safe fabrics and surfaces. You can use it to remove stains from your mattress, upholstery, or fabric, or to clean your carpets, floors, or cribs. This all natural cleaning product is free of chemicals, making it safe for your home and family.
-
This mattress cleaner spray is tough on stains, safe for kids and pets, and all natural. If you’re unhappy with the product, the company will replace it or refund your purchase.
Mattress Cleaner Spray FAQs
1. What are the active ingredients in mattress cleaner spray?
There are many active ingredients in mattress cleaner spray, but some of the most common are enzymes, surfactants, and solvents.
2. How does mattress cleaner spray work?
The ingredients in most mattress cleaners are designed to break down oils and dirt that can accumulate on mattresses. When sprayed on a mattress, the cleaner will usually foam up and then dry quickly, leaving the mattress clean and refreshed.
3. How long does mattress cleaner spray last?
Most mattress cleaner spray bottles come with expiration dates. Check the expiration date on your bottle to see how long it will last.
4. How often should I use mattress cleaner spray?
There is no definitive answer to this question as it depends on a number of factors, such as how often you use your mattress, how often you wash your sheets, and whether or not you have pets. However, a good rule of thumb is to use mattress cleaner spray every three to six months.
5. Does mattress cleaner spray kill dust mites?
Most mattress cleaners are designed to kill dust mites, although there are a few exceptions. Always check the label to be sure.
Conclusion
There are many great mattress cleaner spray on the market. Our list of the best mattress cleaner spray will help you save time researching and choosing the best one for you.